Organisers

Valeria Poli
Salvatore Oliviero
Daniela Taverna

Under the aegis of

SCUOLA DI MEDICINA

SCUOLA DI DOTTORATO
IN SCIENZE DELLA VITA
E DELLA SALUTE

Programme

1 July
2 July
3 July
Posters

Wednesday, 1 July

12:30-14:45	Registration
14:45-15:00	Welcome Addresses Lorenzo Silengo & Gennaro Ciliberto
Session I	The genome and its epigenetic modifications Chair: Salvatore Oliviero
15:00-15:40	Roberto Mantovani (Milan) The structure and genomic strategy of the sequence-specific histone NF-Y
15:40-16:00	Short talk: Dario Antonini (Naples) Dissecting the molecular mechanisms at the basis of impaired p63 transcriptional activity in AEC syndrome
16:00-16:40	Ernesto Guccione (Singapore) Interplay between MYC, TERT and PRMT5 in lymphomagenesis: new partners in crime?
16:40-17:00	Short talk: Benedetto Giaimo (Giessen, Germany) A phospho-dependent mechanism controls a committed chromatin state at Notch target genes
17:00:17:30	Coffee break
17:30-18:20	Chiara D’Onofrio Lecture Massimiliano Mazzone (Leuven, Belgium) Tumor hypoxia and metastatic cancer: a 15-year journey revisiting the biology of cancer cells, blood vessels and inflammation
18:20-20:30	Posters I (odd numbers) & Wine and Cheese

Thursday, 2 July

Session II	Genomes and epigenomes: non-coding RNAs Chair: Daniela Taverna
8:30-9:10	Guido Tarone Lecture Pier Paolo Pandolfi (Turin/Cambridge, MA, USA) The non-coding RNA revolution in biomedical research
9:10-9:30	Short talk: Monica Raimo (Turin) microRNA-146a exerts a dual role in melanoma controlling the Notch-Akt pathway and modulating metastasis-related molecules
9:30-10:10	Alessandro Fatica (Rome) Long non-coding RNAs: new players in acute myeloid leukemia
10:10:10:30	Coffee break
10:30:11:10	Epigen Lecture Doug Turner (Rochester, NY, USA) Folding Influenza RNA
11:10-11:30	Short talk: Alice Conigliaro (Rome) CD90⁺ Liver Cancer Cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
11:30-12:10	Anders Lund (Copenhagen, Denmark) Small RNA host genes in cancer
12:10-13:10	Supporter' talks Antonio Sorrentino (Exiqon) LNA tools to study ncRNA function in vivo Giuseppe Mancuso (Promega) NanoBRET(TM): a breakthrough technology to study chromatin interactions in living cells Paolo Del Porro (Carlo Erba) Reagents, partner in your choice Dario Savoia (Merck) SmartFlareT Live Cell RNA Detection Probes tba (VWR International PBI) Il partner ideale al servizio del cliente Claudio Comunian (Campoverde) ETALUMA: Microscopy simplified
13:10:14:10	Lunch
Session III	Molecular interactions Chair: Valeria Poli
14:10-14:50	Marco Bianchi (Milan) HMGB1 as a DNA chaperone
14:50-15:10	Short talk: Valentina Speranzini (Pavia) Mechanisms of nucleosome recognition by histone demethylase complex LSD1-CoREST
15:10:15:50	Gunter Meister (Regensburg, Germany) RNA binding proteins: managers of coding and non-coding RNA pathways
15:50-16:10	Short talk: Alfredo De Biasio (Trieste) Integrative structural biology unveils the structure of the p15^PAF-PCNA complex: functional implications in DNA replication and repair
16:10-17:50	Poster Session II (even numbers) & coffee break
17:50-18:30	Science and Society: EMBO Science Policy Lecture
	Iain Mattaj (EMBL Director General) EMBL as a model for European Life Science Research and Policy
18:30-19:00	Extraordinary SIBBM Society meeting (members only)
19:00-20:00	General SIBBM Society meeting (members only)
20:00	Dinner at the MBC Court & Posters

Friday, 3 July

Session IV	Molecular Biology and its applications Chair: Gennaro Ciliberto
8:30-9:10	Riccardo Cortese (Keires AG, Basel, Switzerland) Genetic vaccines against emerging and re-emerging diseases
9:10-9:30	Short talk: Cristina Di Primio (Pisa) A new intramolecular biosensor reveals Tau conformational changes in pathological conditions
9:30-10:10	Saverio Minucci (Milan) Epigenetic therapy of acute myeloid leukemias
10:10-10:30	Short talk: Giuseppina Covello (Trento) Correction of FTDP17-associated splicing mutations in MAPT gene via Antisense Oligonucleotide-induced Exon Skipping
10:30:11:00	Coffee break
11:00-11:20	Short talk: Diego Cotella (Novara) Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins
11:20-12:00	Tudor A. Fulga (Oxford, UK) Deciphering miRNA-target regulation by site-specific genome engineering
12:00-12:40	Armenise-Harvard lecture
	Andrea Lunardi (Trento) A genetic platform to model sarcomagenesis
12:40-13:00	Awards: Chiara d'Onofrio giovani, travel and poster awards
	Concluding remarks

Posters

Posters with an odd number are presented during Poster Session I (Wednesday, 1 July). Posters with an even number are presented during Poster Session II (Thursday, 2 July).

The poster's maximum size is 80cm x 120cm (width x height).

P.1 Luigi Alfano (Mercogliano)

HUR protects NONO mRNA from mir320a-mediated degradation upon exposure to UV radiations

P.2 Alessandra Allione (Turin)

Novel epigenetic changes unveiled by monozygotic twins discordant for smoking habits

P.3 Tonino Alonzi (Rome)

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

P.4 Maddalena Arigoni (Turin)

Exosome transcriptome as reservoir of new biomarkers in Leukemia

P.5 Lidia Avalle (Turin)

MicroRNAs-143 and -145 are induced by TGF-β and contribute to mammary epithelium EMT and tumour cell migration and invasion

P.6 Ilenia Aversa (Catanzaro)

The silencing of H-ferritin gene induced EMT in MCF7 cells is accompanied by ROS increase and miR125b down-regulation

P.7 Claudia Badiale (Pavia)

Epigenetic specification of the centromeric function in the absence of satellite DNA

P.8 Cecilia Bandini (Turin)

IRF4 mediates the oncogenic effects of STAT3 in ALK positive anaplastic large cell lymphoma

P.9 Lorenzo Bascetta (Trieste)

Unveiling the oncogenic role of a mutant-p53/miR-30d axis in breast cancer

P.10 Elisa Bergamo (Verona)

The human T-cell leukemia virus -2 (HTLV-2) antisense protein APH-2 interacts with p65 and inhibits NF-ĸB Tax-2 activation

P.11 Ian Bonapace (Busto Arsizio)

UHRF1 monoubiquitination of histone H3K18 is required by DNMT1 for DNA methylation

P.12 Raffaele Calogero (Turin)

circRNA detection: exome-capture versus non-poly(A)-selected RNA-seq

P.13 Manuel Caputo (Trieste)

DEPDC1, a pin1/mutant p53 modulated gene, can impact on aggressiveness in triple negative breast cancer

P.14 Beatrice Cardinali (Monterotondo, RM)

Identification and analysis of new miRNA-222 targets involved in myogenesis

P.15 Elisabetta Casalone (Turin)

Whole blood DNA methylation changes are associated to Malignant Pleural Mesothelioma

P.16 Francesco Chiuso (Naples)

Ubiquitin-dependent control of Ras signaling by cAMP

P.17 Lucia Cicchillitti (Rome)

Identification of a novel NF-Y protein partner: the role of NF-Y/LMNA nuclear complex

P.18 Roberto Coppo (Turin)

ESDN expression in the tumor microenvironment coordinates melanoma progression

P.19 Claudia Coronnello (Palermo)

Compilation of a gene/miRNA expression profile dataset for miRNA:mRNA interactome analysis

P.20 Maria Costantini (Naples)

The seleno-transcriptome expression in two human breast cancer cell lines compared to one human non-cancerous breast epithelial cell line

P.21 Santina Cutrupi (Orbassano, TO)

Estrogen regulates neuroglobin transcription in neuronal cells

P.22 Sara De Iudicibus (Trieste)

miRNA regulation during glucocorticoid treatment in children with inflammatory bowel disease

P.23 Maria Chiara De Santis (Turin)

PI3KC2α, a new spindle associated protein involved in genomic instability and tumorigenesis

P.24 Giorgia Del Vecchio (Rome)

MiR-200 family and HuR play a new game in the regulation of the proto-oncogene c-Jun

P.25 Floriana Della Ragione (Naples)

MeCP2 is required for major satellite forward transcript recruitment at pericentric heterochromatin during neural differentiation

P.26 Daniela Dettori (Turin)

Role of miRNA-214 in melanoma progression

P.27 Alessia Di Silvestre (Trieste)

Identification of cellular models to study the role of the long noncoding RNA GAS5 as modulator of glucocorticoid response

P.28 Chiara Stella Di Stadio (Naples)

Epigenetic regulation of Gastrokine 1 (GKN1) gene in gastric cancer

P.29 Roberta Esposito (Salerno)

Helicobacter pylori induced epigenetic changes in cellular models

P.30 Emmanuela Falcone (Rome)

Study of a novel transcription factor-miRNAs circuit in EMT of colon cancer cells

P.31 Luigi Fattore (Naples)

miR-579-3p targets the mutant BRAF oncogene acting as an oncosuppressor in metastatic melanoma

P.32 Giulio Ferrero (Turin)

Integrative strategies for omics data: ERα cistrome and epigenome case-study

P.33 Xavier Filella (Barcelona, Spain)

Urinary miR-21-5p and miR-141-3p as potential biomarkers for prostate cancer

P.34 Claudia Vincenza Fiumara (Catanzaro)

Selective dicer suppression in kidney mouse: proteomics analysis

P.35 Federica Fusella (Turin)

Morgana: a novel player in apoptosis resistance and metastasis progression in breast tumorigenesis

P.36 Simonetta Guarrera (Turin)

Genome-wide DNA methylation profiling in myocardial infarction

P.37 Francesca Guerrieri (Rome)

HBx directly binds DLEU2 lncRNA and affect chromatin transcription

P.38 Andrea Iannello (Orbassano, TO)

Estrogen receptor alpha role in Th17 and Treg cells balance during pregnancy of multiple sclerosis patients

P.39 Danny Incarnato (Turin)

Transcriptome-wide inference of native deproteinized RNA secondary structures

P.40 Anna Krepelova (Turin)

Identification of high-fidelity Myc and Max genomic targets in mouse embryonic stem cells

P.41 Shraddha Lad (Naples)

Dynamics of the imprinting maintenance ZFP57/KAP1 and associated factors network at DNA methylated targets in pluripotent ES cells and insights into a potential developmental/differentiation role

P.42 Marianna Lucafò (Trieste)

Potential role of long noncoding RNA GAS5 in rapamycin-induced reversion of glucocorticoid resistance

P.43 Filippo Macchi (Busto Arsizio)

DNA hypo- and hyper-methylation in colon cancer: may UHRF1 decrypt the epigenetic basis of the paradox?

P.44 Elena Magnani (Busto Arsizio)

Natural antisense long non-coding RNA regulates E-cadherin expression in prostate cancer cells

P.45 Mara Maldotti (Turin)

CCR_11 and CCR_03: two long intergenic non-coding RNAs involved in cell cycle control

P.46 Martina Mandruzzato (Busto Arsizio)

Carcinogen–induced epigenetic alteration on chromatin in human retroelements (LINE-1): instauration of histone bivalent marks after in vitro treatment with hydroquinone in HL60 cells

P.47 Fiamma Mantovani (Trieste)

Dissecting the tumor suppression activity of the bromodomain-containing protein BRD7

P.48 Federica Marasca (Rome)

A cytosolic Ezh1 isoform modulates PRC2-Ezh1 repressive function as adaptive epigenetic response in post-mitotic cells

P.49 Jessica Marinello (Bologna)

Topoisomerase I-dependent DNA breaks accumulate antisense and sense transcripts in promoter regions prone to R-loop formation

P.50 Francesca Martinetto (Verona)

New insights into FOXP2 alternative splicing

P.51 Miriam Martini (Turin)

Loss of PI3KC2A promotes aneuploidy in breast cancer and sensitivity to anti-mitotic agents

P.52 Elisabetta Mereu (Turin)

Identification of a new subclass of ALK negative ALCL expressing aberrant levels of ERBB4 transcripts

P.53 Angela Messina (Catania)

Regulation of VDAC1 translation by alternative 5'UTR in Drosophila melanogaster

P.54 Valentina Miano (Orbassano, TO)

Detection and role of circular RNAs in breast cancer

P.55 Catia Mio (Udine)

Effect of BET inhibition on anaplastic thyroid cancer cells

P.56 Enrico Moiso (Turin)

Overexpression of the muscle specific chaperone Melusin delays heart failure and mortality in a mouse model of Emery Dreyfus cardiomyopathy

P.57 Emanuele Monteleone (Turin)

Potential role of Stat3 in controlling pluripotency and differentiation via lincRNAs transcriptional regulation

P.58 Deborah Morena (Turin)

A HGF-induced multistep model of Rhabdomyosarcoma based on by passing stem cell quiescience, recapitulates the heterogeneity of the human ERMS subtype

P.59 Giovanni Morrone (Catanzaro)

Functional interaction of the stem cell-associated transcription co-factor, Zinc finger protein 521 (ZNF521), with the Hedgehog (HH) signalling pathway

P.60 Daniele Musiani (Milan)

Unraveling the plasticity of the arginine methylome in the DNA damage response by high-resolution mass spectrometry-based proteomics

P.61 Carmelo Neri (Trieste)

Unveiling new signaling pathways contributing to oncogenic activities of mutp53-R249S

P.62 Francesco Neri (Turin)

Single-base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals DNA methylation/demethylation dynamics in the mammalian genome

P.63 Valerio Orlando (Thuwal, Saudi Arabia)

Role of the mobile genome in cell identity, reprograming and disease

P.64 Francesca Orso (Turin)

MiR-214 overexpressing mice develop amyloidosis and more aggressive mammary gland tumors

P.65 Emiliano Panieri (Turin)

Real-time detection of ROS and redox changes in the vascular system during physiological and pathological settings

P.66 Ilaria Panzeri (Milan)

Long intergenic non-coding RNAs: novel drivers of human lymphocyte differentiation

P.67 Barbara Pardini (Turin)

A next generation sequencing approach for microRNA profiling in plasma for bladder cancer characterization

P.68 Laura Patrucco (Novara)

RIDome: drafting the RNA-binding proteome through the selection of open reading frames

P.69 Giulia Piaggio (Rome)

Imaging of proliferation during mammary tumorigenesis reveals a crosstalk between cancer and host macroenviroment

P.70 Valeria Poli (Turin)

The non-canonical Wnt/Planar Cell Polarity pathway can trigger transcriptional activation via JNK-mediated Sp1 phosphorylation: synergy with STAT3 in basal like breast cancer

P.71 Cristina Potrich (Povo, TN)

On-chip purification and detection of Hepatitis C Virus RNA from human plasma

P.72 Lorena Quirico (Turin)

Dual targeting of miR-214 and miR-148b leads to metastasis inhibition via ALCAM and ITGA5

P.73 Marzia Raimondi (Padriciano, TS)

Calpain restrains the stem cells compartment in a model of basal like breast cancer

P.74 Stefania Rapelli (Turin)

Identification and functional characterization of a novel lincRNAs, dal389, involved in neuronal differentiation lineage

P.75 Stefania Reineri (Orbassano, TO)

Tab2 regulates ERα activity and resistance to endocrine therapy

P.76 Stefania Rocca (Turin)

Morgana acts as oncosuppressor in chronic myeloid leukemia

P.77 Antonella Romano (Naples)

Mechanism of estrogen and retinoic-induced transcription: histone code, DNA oxidation and chromatin loops

P.78 Giuseppe Roscilli (Rome)

ErbB3 targeting to overcome resistance to tyrosine kinase inhibitors

P.80 Alessia Russo (Turin)

Smoking habits are associated with methylation age

P.81 Marco Santagostino (Pavia)

A transposon insertion in the horse myostatin gene promoter inhibits its expression and influences racing performance

P.82 Roberto Santoro (Turin)

Exploring the role of alternative poly-adenylation sites and 3’ UTRs length during differentiation of inhibitory neurons, via RNAseq

P.83 Emanuele Sasso (Naples)

A nucleolar function for carbonic anhydrase IX in human cells

P.84 Margherita Scarpato (Naples)

A regulatory crosstalk in Down syndrome: competing mRNA-miRNA network

P.85 Laura Seclì (Turin)

Extracellular Morgana induces migration in breast cancer cells

P.86 Beatrice Tassone (Turin)

Abnormalities in keratinocyte proliferation and apoptosis in mice with a conditional deletion of rictor in the epidermis

P.87 Silvia Tonon (Udine)

Is epigenetics controlling IL-10 production in B cells?

P.88 Marco Tripodi (Rome)

HOTAIR/EZH2 complex recruitment to specific genomic sites in Epithelial to Mesenchymal Transition

P.89 Valentina Villano (Naples)

Gastrokine 1 as a possible informative biomarker of gastric cancer

P.90 Ilaria Voto (Trieste)

Dissecting the tumor suppression activity of the bromodomain-containing protein BRD7

P.91 Francesca Zanconato (Padua)

Identification of a YAP/TAZ/TEAD transcriptional program driving oncogenic growth

P.92 Manuela Zanetti (Trento)

Pore forming toxins: powerful molecular medicine factors

P.93 Lorena Zubovic (Trento)

Sequence-specific RNA binding by Rbfox1 and Rbfox2 proteins regulate miRNA biogenesis

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